新しい心毒性防御遺伝子stannniocalcin1の臨床応用
PDXZ and Tour Angiogenesis Analysis
Aging-associated microstructural deterioration of vertebra in zebra fi sh
zebrafish認知症モデルスクリーニングによる新規治療薬開発の成功例
foods that are typically used in diet-induced zebrafish type 2 diabetes mellitus models
Zebrafish are small, transparent fish that are widely used in biomedical research. They are a powerful tool for drug discovery, as they are easy to breed and maintain in the laboratory, and their embryos develop quickly and are transparent, making it possible to track the effects of drugs on developing tissues and organs.
Zebrafish have been used to identify and validate drug targets for a wide range of diseases, including cancer, heart disease, diabetes, and neurodegenerative disorders. They have also been used to develop new drug delivery methods and to study the mechanisms of action of existing drugs.
The global development of zebrafish-based drug discovery is being driven by a number of factors, including the increasing cost of drug development, the need for more efficient and effective drug discovery methods, and the growing recognition of the importance of zebrafish as a model organism for human disease.
In the future, zebrafish-based drug discovery is likely to play an even greater role in the development of new and improved treatments for human diseases. As zebrafish research continues to advance, scientists will gain a deeper understanding of the molecular basis of human disease, and they will be able to develop more targeted and effective drugs.
Here are some specific examples of how zebrafish are being used in drug discovery:
・ Zebrafish have been used to identify and validate drug targets for cancer. For example, a study published in 2016 identified a new drug target for pancreatic cancer in zebrafish. This discovery led to the development of a new drug that is now in clinical trials for the treatment of pancreatic cancer.
・ Zebrafish have been used to develop new drug delivery methods. For example, a study published in 2017 developed a new way to deliver drugs to the brain using zebrafish. This method could potentially be used to deliver drugs to the brain for the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease.
・ Zebrafish have been used to study the mechanisms of action of existing drugs. For example, a study published in 2018 used zebrafish to study the mechanism of action of a drug for the treatment of malaria. This study provided new insights into how the drug works, which could lead to the development of new and improved drugs for the treatment of malaria.
The global development of zebrafish-based drug discovery is a promising area of research that has the potential to lead to the development of new and improved treatments for human diseases.