医療ビッグデータ時代における次世代AIDXゼブラフィッシュ創薬研究開発
ゼブラフィッシュによるOncocardiologyとOnconephrology
Personalized cancer treatment using PDX zebrafish model
The world's most powerful high-throughput individualized in vivo proteinuria screening system
in vivo 血漿蛋白蛍光色素ZMB741による蛋白尿定量スクリーニング
蛍光色素ZMB741は、なぜ非観血的投与によりすべての血漿タンパク質をラベルできるのか。
The world's most powerful high-throughput individualized in vivo proteinuria screening system is reported below.
In Vivo Assessment of Individual and Total Proteinuria in Zebrafish Larvae Using the Solvatochromic Compound ZMB741 | Chemical & Biomedical Imaging https://pubs.acs.org/doi/10.1021/cbmi.4c00029
2013 (ACS Chem Neurosci. 4:1183-93), we independently developed a novel fluorescent dye ZMB741 that rapidly binds to plasma proteins of all molecular weights in vivo when added to zebrafish rearing water and demonstrated its overwhelming superiority in the non-invasive, individual in We have developed a non-invasive, non-invasive zebrafish individual in vivo proteinuria quantification protocol for nephrotoxic proteinuria. As a result, we report the creation of an in vivo high-throughput nephrotoxicity screening system based on a completely new principle that can discriminate between glomerular and urinary repopulation disorders of nephrotoxicity.
We expect that this system will be utilized in a wide range of fields in the future.
(1) High-throughput screening for nephrotoxicity and analysis of nephrotoxicity mechanism
(1) Aristolochic Acid, (2) Monacolin K, Citrinin
(3) Puromycin Aminonucleoside (PAN)
(2) High-throughput screening of prophylactic regulators for nephrotoxicants and
(1) Resveratrol
(1)Resveratrol
(3) Pathogenetic analysis of human proteinuria disease model
(1)Glomerular Basement Membrane (GBM) Genes: laminin, collagen IV
(2)Podocyte-specific Genes: nephrin(nphs1), podocin(nphs2)
(4) High-throughput screening and mechanism of action analysis of therapeutic agents for human proteinuric diseases
Translated with www.DeepL.com/Translator (free version)
The world's most powerful high-throughput individualized in vivo proteinuria screening system
ZEBRAFISH-BASED QUANTITATIVE AND SYSTEMS PHARMACOLOGY
high-throughput individualized in vivo proteinuria screening system
The world's most powerful high-throughput individualized in vivo proteinuria screening system
