医療ビッグデータ時代における次世代AIDXゼブラフィッシュ創薬研究開発
ゼブラフィッシュによるOncocardiologyとOnconephrology
Personalized cancer treatment using PDX zebrafish model
The world's most powerful high-throughput individualized in vivo proteinuria screening system
in vivo 血漿蛋白蛍光色素ZMB741による蛋白尿定量スクリーニング
蛍光色素ZMB741は、なぜ非観血的投与によりすべての血漿タンパク質をラベルできるのか。
Personalized cancer treatment using patient-derived xenografts in zebrafish is a rapidly developing area of research with the potential to revolutionize cancer care. Here's a breakdown of the process and its key aspects:
The Process:
Tumor Sample Collection: A small sample of a patient's tumor is extracted through a biopsy or surgery.
Zebrafish Embryo Preparation: Zebrafish embryos are bred and raised in controlled laboratory settings.
Tumor Transplantation: Tiny pieces of the patient's tumor are implanted into a specific location within the zebrafish embryo, often the yolk sac.
Drug Testing: Different potential cancer drugs are administered to the zebrafish containing the patient's tumor cells.
Tumor Monitoring: Researchers closely observe the growth and response of the tumors in the zebrafish embryos over time.
Drug Response Evaluation: Based on the tumor growth patterns, scientists can identify the most effective drugs for the patient's specific cancer.
Advantages:
Personalized Medicine: Drugs are selected based on the patient's tumor's unique response, potentially leading to more effective treatment.
Rapid Assessment: Zebrafish embryos develop quickly, allowing for faster evaluation of drug efficacy compared to traditional methods.
Cost-Effectiveness: Using zebrafish embryos is a relatively inexpensive way to test potential drugs.
Ethical Considerations: Zebrafish are invertebrates and likely don't experience pain, addressing ethical concerns present with some animal models.
Limitations:
Species Differences: While zebrafish share genetic similarities with humans, there might be discrepancies in drug metabolism and tumor behavior.
Tumor Complexity: Zebrafish embryos might not fully represent the intricate nature of human tumors, especially advanced or metastatic cancers.
Clinical Translation: Further research is needed to confirm the findings from zebrafish studies and translate them into successful clinical treatment strategies.
Overall, this approach holds promise for:
Developing individualized treatment plans: Tailoring treatment based on a patient's specific cancer can potentially improve outcomes.
Identifying new and more effective cancer drugs: Faster drug testing allows for quicker development of new treatment options.
Personalized cancer treatment using PDX zebrafish model
Personalized cancer treatment using PDX zebrafish model
