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2019/03/18
Zebrafish yolk sac microinjection of thalidomide for assessment of developmental toxicology

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Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test

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Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish.

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EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

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Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch.

tCalmodulin antagonists enhance calcium binding to calmodulin.

                     
1983/01/01

Pharmacology. 1983;27(3):125-9.

Calmodulin antagonists enhance calcium binding to calmodulin.

Inagaki M, Tanaka T, Hidaka H.


Abstract

The effects of calmodulin (CaM) antagonists, N-(6-aminohexyl)(-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives or trifluoperazine (TFP) on the Ca2+ binding to CaM were investigated. In the presence of these CaM antagonists, the extent of the Ca2+ binding to CaM increased. Stoichiometrical Examination showed that these CaM antagonists dose-dependently increased the sensitivity of all four Ca2+ binding sites on CaM. An analysis of CaM by UV spectroscopy revealed that the conformation of the Ca2+ CaM complex in the presence and absence of these CaM antagonists differed. Therefore, binding of this CaM antagonist to CaM increase the binding of Ca2+ to this protein.


PMID: 6622516 [PubMed - indexed for MEDLINE]

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Pubmed