Publication List English

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch.

New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae.

Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 12 axis in early-stage age-related macular degeneration

Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish

tCalmodulin antagonists enhance calcium binding to calmodulin.


Pharmacology. 1983;27(3):125-9.

Calmodulin antagonists enhance calcium binding to calmodulin.

Inagaki M, Tanaka T, Hidaka H.


The effects of calmodulin (CaM) antagonists, N-(6-aminohexyl)(-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives or trifluoperazine (TFP) on the Ca2+ binding to CaM were investigated. In the presence of these CaM antagonists, the extent of the Ca2+ binding to CaM increased. Stoichiometrical Examination showed that these CaM antagonists dose-dependently increased the sensitivity of all four Ca2+ binding sites on CaM. An analysis of CaM by UV spectroscopy revealed that the conformation of the Ca2+ CaM complex in the presence and absence of these CaM antagonists differed. Therefore, binding of this CaM antagonist to CaM increase the binding of Ca2+ to this protein.

PMID: 6622516 [PubMed - indexed for MEDLINE]