Publication List English

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Chemokines protect vascular smooth muscle cells from cell death induced by cyclic mechanical stretch.

New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae.

Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 12 axis in early-stage age-related macular degeneration

Activation of Sterol Regulatory Element Binding Factors by Fenofibrate and Gemfibrozil Stimulates Myelination in Zebrafish

tCalmodulin-dependent calcium signal transduction.


Tanaka T.
Jpn J Pharmacol. 1988 Feb;46(2):101-7.


Calmodulin (CaM) is a ubiquitous, intracellular calcium-receptive protein. Biopharmacological studies using CaM antagonists suggest that CaM is involved in mechanisms of stimulus-induced cellular responses such as smooth muscle contraction, secretion of nonmuscle cells and cell proliferation. Results with these CaM antagonists, hydrophobic fluorescent probes, hydrophobic chromatography, and alternative activators of Ca2+, CaM-dependent enzyme revealed that calcium ion induces conformational changes in CaM that expose hydrophobic regions on the surface of the molecule, and these regions may act as sites of interaction with its target enzymes and CaM antagonists. Moreover, a similar molecular mechanism of calcium signal transduction was also observed with other calcium-modulated proteins such as troponin C and S100 protein.