Publication List English

Generation of a Transgenic Zebrafish Line for In Vivo Assessment of Hepatic Apoptosis

Patient-Derived Cancer Xenograft Zebrafish Model (PDXZ) for Drug Discovery Screening and Personalized Medicine

Quality Control Protocol for Zebrafish Developmental Toxicity Studies

Gap junction protein beta 4 plays an important role in cardiac function in humans, rodents, and zebrafish

A novel orexin antagonist from a natural plant was discovered using zebrafish behavioural analysis

tCalmodulin-dependent calcium signal transduction.


Tanaka T.
Jpn J Pharmacol. 1988 Feb;46(2):101-7.


Calmodulin (CaM) is a ubiquitous, intracellular calcium-receptive protein. Biopharmacological studies using CaM antagonists suggest that CaM is involved in mechanisms of stimulus-induced cellular responses such as smooth muscle contraction, secretion of nonmuscle cells and cell proliferation. Results with these CaM antagonists, hydrophobic fluorescent probes, hydrophobic chromatography, and alternative activators of Ca2+, CaM-dependent enzyme revealed that calcium ion induces conformational changes in CaM that expose hydrophobic regions on the surface of the molecule, and these regions may act as sites of interaction with its target enzymes and CaM antagonists. Moreover, a similar molecular mechanism of calcium signal transduction was also observed with other calcium-modulated proteins such as troponin C and S100 protein.