TOPICS
2024/11/07
２１世紀におけるゼブラフィッシュ創薬のグローバル展開
2024/10/25
AIDXゼブラフィッシュ創薬のグローバル展開
2024/10/15
三重大学大学院システムズ薬理学の展開
2024/10/05
システムズ薬理学大学院大募集中です。
2024/09/10
Zebrafish-Based Oncocardionephrology
》第135号 Flash News「がん治療の新たな光となる新規治療標的遺伝子を発見」
2014/09/30
第135号 Flash Newsに9/18の記者会見の模様が掲載されました。
Abstract
Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.