TOPICS
2025/10/22
AI プレシジョン患者がん移植ゼブラフィッシュシステムのプロトコル開発
2025/10/16
AIDXプレシジョン患者がん移植システムによるゼブラフィッシュ創薬と個別化医療
2025/10/07
AIプレシジョン患者がん移植ゼブラフィッシュシステムの急展開
2025/10/02
臨床治療応答予測のためのin vitro診断ツール：PDXZ
2025/06/23
患者がん移植ゼブラフィッシュモデル(PDXZ)の臨床応用
》Next Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine
2014/12/10
We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drug’s multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.