》第84回日本薬理学会年会シンポジウム

2011/03/23

第84回日本薬理学会年会が2011年3月22日-24日にパシフィコ横浜にて開催されます。シンポジウム 20「次世代分子イメージング創薬への展望」（23日10時30分縲?12時）において下記の演題を発表します。当日会場へのご参加を，お待ちしております。

新しいin vivoイメージングとオミックス創薬

西村有平、島田康人、田中利男
三重大学大学院医学系研究科薬理ゲノミクス
三重大学メディカルゼブラフィッシュ研究センター
三重大学生命科学研究支援センターバイオインフォマティクス
三重大学VBLメディカルケモゲノミクス研究室

Application of novel in vivo imaging and omics technology in drug discovery

The recent developments of combinatorial chemistry call for systems that can be used for high throughput screening to examine in vivo properties of small molecules and their target genes early in the drug discovery process. Small molecules identified by the in vivo screening are likely to be cell permeable, less toxic, effective and with an acceptable pharmacokinetic and pharmacodynamic profile. Zebrafish have been useful for the in vivo high throughput chemical screening to identify drug leads and explore new application for known drugs. Being a vertebrate, zebrafish share many common features with humans in anatomy and physiological responses. The external and rapid development as well as transparency of zebrafish embryos is ideal for phenotype-based screening at cellular and organ level by combination of live imaging. The assessment of phenotype includes changes in morphogenesis, behaviors and mortality. Through the phenotype-based screening, chemicals that induce a phenotype of interest can be selected, followed by identifying targets of the chemicals using various omics technologies. In this symposium, we will show our zebrafish-based small molecule screenings, especially focusing on screening of a diversity-oriented fluorescent library.

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》第84回日本薬理学会年会シンポジウム

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