Publication List English

2019/10/15
C3orf70 Is Involved in Neural and Neurobehavioral Development

2019/09/22
Generation of a Triple-Transgenic Zebrafish Line for Assessment of Developmental Neurotoxicity during Neuronal Differentiation

2019/07/17
Aging-associated microstructural deterioration of vertebra in zebrafish

2019/03/18
Zebrafish yolk sac microinjection of thalidomide for assessment of developmental toxicology

2019/02/18
Toxicological Evaluation of SiO2 Nanoparticles by Zebrafish Embryo Toxicity Test

tEriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

                     
2014/01/15

Masanori Hiramitsu, Yasuhito Shimada,Junya Kuroyanagi,Takashi Inoue,Takao Katagiri,Liqing Zang,Yuhei Nishimura,Norihiro Nishimura & Toshio Tanaka
Scientific Reports 4, Article number: 3708 doi:10.1038/srep03708 Received 12 April 2013 Accepted 10 December 2013 Published 15 January 2014

Lemon (Citrus limon) contains various bioactive flavonoids, and prevents obesity and obesity-associated metabolic diseases. We focused on eriocitrin (eriodictyol 7-rutinoside), a powerful antioxidative flavonoid in lemon with lipid-lowering effects in a rat model of high-fat diet. To investigate the mechanism of action of eriocitrin, we conducted feeding experiments on zebrafish with diet-induced obesity. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. DNA microarray analysis revealed that eriocitrin increased mRNA of mitochondrial biogenesis genes, such as mitochondria transcription factor, nuclear respiratory factor 1, cytochrome c oxidase subunit 4, and ATP synthase. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading. Eriocitrin increased mitochondrial size and mtDNA content, which resulted in ATP production in HepG2 cells and zebrafish. In summary, dietary eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis.

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Pubmed

Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

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Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis