Research

2017/03/13

IoZ(Internet of Zebrafish) の新しい展開

2016/10/13

NEDO PROJECT SUCCESS STORIES

2014/04/07

新しい肥満遺伝子MXD3の発見と展開 (管理者)

2014/04/07

全世界全分野518名の一人として中国政府研究賞を受賞 (管理者)

2013/04/22

三重大学 医学部News No.173 2013.4.1発行

2013/03/18

中国向けサイト【客観日本】:「食行動の謎、(透明ゼブラフィッシュ)で研究をスピードアップ―三重大学」

2012/12/26

The Pharmacology of Mie University

2011/12/19

A Novel Protocol for the Oral Administration of Test Chemicals to Adult Zebrafish (管理者)

2011/04/21

天才的マイクロインジェクション

2010/10/31

治療に臨んでは、地球を一大国と定める。

》The Pharmacology of Mie University

                     
2012/12/26

Pharmacogenomics and Systems Pharmacology

The Pharmacology of Mie University has particular strengths in the areas of pharmacogenomics and systems pharmacology on cellular signaling mechanisms and gene expression as targets of drug action. Systems pharmacology is defined to identify the gene network which are involved in determining the responsiveness and to distinguish responders and non-responders to a given drug. Genome sequensing, transcriptome, proteome and metabolome analysis are of particular significance in pharmacogenomics. Sequencing is used to locate polymorphisms, and monitoring of functional gene expression can provide clue about the genomic response to disease and treatment. The transcriptome analysis can be done by next generation DNA sequencer and oligomicrochip differential hybridization. We use multiomics analysis to identify and validate therapeutic target genes by studying change of gene expression in human cells and zebrafish model of various human diseases and find novel drug target candidates through this systems pharmacology strategy. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development in zebrafish. Recent study validates the zebrafish as an effective model for not only drug discovery but also drug optimization. The pharmacogenomics and systems pharmacology has the potential for strategy to define novel drug targets in various diseases of unmet medical needs and holds the promise that drugs might be tailor-made for individuals and adapted to each person’s own genetic makeup.

http://zqsp-mie-u.org/zqsp/

関連リンク

三重大学大学院医学系研究科薬理ゲノミクスHP

三重大学バイオインフォマティクスHP