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2011/03/23

第84回日本薬理学会年会で発表します

2011年3月22日-24日にパシフィコ横浜にて開催されます第84回日本薬理学会年会において、「新しいヒト癌移植モデルにおける腫瘍血管新生のハイコンテンツ解析」の表題で発表します。

High-content Analysis of Tumor Angiogenesis in Novel Human Cancer Transplant ation Model.

Kuroyanagi Junya1, Shimada Yasuhito1234, Nishimura Yuhe1234,Tanaka Toshio1234
1Dept. Pharmacogenomics.,Mie Univ. Sch. Med.
2Mie University Medical Zebrafish Research Center
3Department of Bioinformatics, Mie University Life Science Research Cente
4Department of Medical Chemogenomics, Mie University Venture Business Laborat ory,

Angiogenesis plays an important role in tumor growth and metastasis. Most tu mors release angiogenesis-regulating factors, and neovasculature occurs when there are predominating positive signaling from regulators of angiogenesis.
The use of agents that can inhibit angiogenesis has indicated that anti-ang iogenic therapy can be a promising therapeutic approach in clinical cancer t reatment. We identified tumor angiogenesis in zebrafish which is one of powe rful models to define gene relevant to human malignant disease because of th e ease of gene manipulation and large scale pharmacological screens. We tran splanted several human cancer cells to zebrafish and analysis the tumor angi ogenesis in vivo. Then, we performed DNA microarray analysis to reveal the t ranscriptome profile of tumor angiogenesis. The pathways identified by the t ranscriptome
analysis included several pathway that are known to be involved in angiogenesis in humans and mice, including MAPK, TGF-&beta and NF-&kappa B pathway. In addition, we discovered the several novel gene clusters which regulate angiogenesis. In summary, we clarified the transcriptome profiles o f the tumor angiogenesis using zebrafish model of human cancer transplantati on.