ZEBRAFISH

National Phenotypic Screening CentreがなぜUKに創設されたか?

top 25% most cited PLOS ONE articlesになりました。

ゼブラフィッシュ創薬のコアテクノジーとしてのゲノム編集

iPS細胞創薬とゼブラフィッシュ創薬

次世代ゼブラフィッシュ創薬の展開

ゼブラフィッシュ蛋白尿スクリーニング

ゼブラフィッシュ産卵障害の解決プロトコール

AAALAC Internationalとは?

DesignSpark Mechanicalを使いこなそう!

Zebrafish Husbandry Associationが日本でも不可欠です。

》次世代ゼブラフィッシュ創薬の展開

                     
2017/06/04

次世代ゼブラフィッシュ創薬は、フェノミクス創薬のコアテクノジーとして発展していくとともに、Internet of Zebrafish(IoZ, IoT)の展開が、大きな基盤となっていきます。

PUBLICATIONS
Sasagawa, S., Nishimura, Y., Sawada, H., Zhang, E., Okabe, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Mitani, Y., Maruyama, K., Tanaka, T. (2016) Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension. Frontiers in pharmacology. 7:142
Saito, Y., Tsuruma, K., Shimazawa, M., Nishimura, Y., Tanaka, T., Hara, H. (2016) Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish. Journal of Pharmacological Sciences. 131(3):215-8
Kawase, R., Nishimura, Y., Ashikawa, Y., Sasagawa, S., Murakami, S., Yuge, M., Okabe, S., Kawaguchi, K., Yamamoto, H., Moriyuki, K., Yamane, S., Tsuruma, K., Shimazawa, M., Hara, H., Tanaka, T. (2016) EP300 Protects from Light-Induced Retinopathy in Zebrafish. Frontiers in pharmacology. 7:126
Sasagawa, S., Nishimura, Y., Hayakawa, Y., Murakami, S., Ashikawa, Y., Yuge, M., Okabe, S., Kawaguchi, K., Kawase, R., Tanaka, T. (2016) E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish. Frontiers in pharmacology. 7:119
Zhang, B., Shimada, Y., Hirota, T., Ariyoshi, M., Kuroyanagi, J., Nishimura, Y., Tanaka, T. (2015) Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Translational research : the journal of laboratory and clinical medicine. 170:89-98.e3
Sasagawa, S., Nishimura, Y., Koiwa, J., Nomoto, T., Shinto, T., Murakami, S., Yuge, M., Kawaguchi, K., Kawase, R., Miyazaki, T., Tanaka, T. (2015) In vivo detection of mitochondrial dysfunction induced by clinical drugs and disease-associated genes using a novel dye ZMJ214 in zebrafish. ACS Chemical Biology. 11(2):381-8
Nishimura, Y., Okabe, S., Sasagawa, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., Tanaka, T. (2015) Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers. Frontiers in pharmacology. 6:257
Zang, L., Shimada, Y., Nishimura, Y., Tanaka, T., Nishimura, N. (2015) Repeated Blood Collection for Blood Tests in Adult Zebrafish. Journal of visualized experiments : JoVE. (102):e53272
Shimada, Y., Kuninaga, S., Ariyoshi, M., Zhang, B., Shiina, Y., Takahashi, Y., Umemoto, N., Nishimura, Y., Enari, H., Tanaka, T. (2015) E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. Nutrition & metabolism. 12:17
Kuroyanagi, J., Shimada, Y., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., Tanaka, T. (2015) Corrigendum to "Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression" [FEBS Lett. 588 (2014) 3409-3416]. FEBS letters. 589:870
Chang, J., Ichihara, G., Shimada, Y., Tada-Oikawa, S., Kuroyanagi, J., Zhang, B., Suzuki, Y., Sehsah, R., Kato, M., Tanaka, T., Ichihara, S. (2015) Copper Oxide Nanoparticles Reduce Vasculogenesis in Transgenic Zebrafish Through Down-Regulation of Vascular Endothelial Growth Factor Expression and Induction of Apoptosis. Journal of nanoscience and nanotechnology. 15:2140-7
Zhang, B., Shimada, Y., Kuroyanagi, J., Ariyoshi, M., Nomoto, T., Shintou, T., Umemoto, N., Nishimura, Y., Miyazaki, T., Tanaka, T. (2015) In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3). Biomaterials. 52:14-25
Kawabata, M., Umemoto, N., Shimada, Y., Nishimura, Y., Zhang, B., Kuroyanagi, J., Miyabe, M., Tanaka, T. (2014) Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. Toxicological sciences : an official journal of the Society of Toxicology. 143(2):374-84
Zhang, B., Shimada, Y., Kuroyanagi, J., Nishimura, Y., Umemoto, N., Nomoto, T., Shintou, T., Miyazaki, T., Tanaka, T. (2014) Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(12):11861-9
Nishimura, Y., Murakami, S., Ashikawa, Y., Sasagawa, S., Umemoto, N., Shimada, Y., Tanaka, T. (2014) Zebrafish as a systems toxicology model for developmental neurotoxicity testing. Congenital Anomalies. 55(1):1-16
Kuroyanagi, J., Shimada, Y., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., Tanaka, T. (2014) Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS letters. 588(18):3409-16
Hiramitsu, M., Shimada, Y., Kuroyanagi, J., Inoue, T., Katagiri, T., Zang, L., Nishimura, Y., Nishimura, N., and Tanaka, T. (2014) Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Scientific Reports. 4:3708
Zhang, B., Shimada, Y., Kuroyanagi, J., Umemoto, N., Nishimura, Y., and Tanaka, T. (2014) Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS One. 9(1):e85439
Shimada, Y., Nishimura, Y., Tanaka, T. (2014) Zebrafish-based systems pharmacology of cancer metastasis. Methods in molecular biology (Clifton, N.J.). 1165:223-38
Shimada, Y., Kuroyanagi, J., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., and Tanaka, T. (2013) Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice. International Journal of Obesity. 38(8):1053-60
Nishimura, Y., Yata, K., Nomoto, T., Ogiwara, T., Watanabe, K., Shintou, T., Tsuboyama, A., Okano, M., Umemoto, N., Zhang, Z., Kawabata, M., Zhang, B., Kuroyanagi, J., Shimada, Y., Miyazaki, T., Imamura, T., Tomimoto, H., and Tanaka, T. (2013) Identification of a Novel Indoline Derivative for in Vivo Fluorescent Imaging of Blood-Brain Barrier Disruption in Animal Models. ACS Chemical Neuroscience. 4(8):1183-93
Umemoto, N., Nishimura, Y., Shimada, Y., Yamanaka, Y., Kishi, S., Ito, S., Okamori, K., Nakamura, Y., Kuroyanagi, J., Zhang, Z., Zang, L., Wang, Z., Nishimura, N., and Tanaka, T. (2013) Fluorescent-Based Methods for Gene Knockdown and Functional Cardiac Imaging in Zebrafish. Molecular Biotechnology. 55(2):131-42
Zang, L., Shimada, Y., Nishimura, Y., Tanaka, T., and Nishimura, N. (2013) A Novel, Reliable Method for Repeated Blood Collection from Aquarium Fish. Zebrafish. 10(3):425-32
Shimada, Y., Hirano, M., Nishimura, Y., and Tanaka, T. (2012) A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS One. 7(12):e52549
Tsuruma, K., Nishimura, Y., Kishi, S., Shimazawa, M., Tanaka, T., and Hara, H. (2012) SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. Investigative ophthalmology & visual science. 53(10):6729-6737
Watanabe, K., Nishimura, Y., Nomoto, T., Umemoto, N., Zhang, Z., Zhang, B., Kuroyanagi, J., Shimada, Y., Shintou, T., Okano, M., Miyazaki, T., Imamura, T., and Tanaka, T. (2012) In vivo assessment of the permeability of the blood--brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neuroscience. 13(1):101
Hasumura, T., Shimada, Y., Kuroyanagi, J., Nishimura, Y., Meguro, S., Takema, Y., and Tanaka, T. (2012) Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish. Nutrition & metabolism. 9(1):73
Tainaka, T., Shimada, Y., Kuroyanagi, J., Zang, L., Oka, T., Nishimura, Y., Nishimura, N., and Tanaka, T. (2011) Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. Nutrition & metabolism. 8(1):88
Zang, L., Morikane, D., Shimada, Y., Tanaka, T., and Nishimura, N. (2011) A novel protocol for the oral administration of test chemicals to adult zebrafish. Zebrafish. 8(4):203-210
Oka, T., Nishimura, Y., Zang, L., Hirano, M., Shimada, Y., Wang, Z., Umemoto, N., Kuroyanagi, J., Nishimura, N., and Tanaka, T. (2010) Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiology. 10:21
Watanabe, K., Nishimura, Y., Oka, T., Nomoto, T., Kon, T., Shintou, T., Hirano, M., Shimada, Y., Umemoto, N., Kuroyanagi, J., Wang, Z., Zhang, Z., Nishimura, N., Miyazaki, T., Imamura, T., and Tanaka, T. (2010) In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neuroscience. 11:116
Wang, Z., Nishimura, Y., Shimada, Y., Umemoto, N., Hirano, M., Zang, L., Oka, T., Sakamoto, C., Kuroyanagi, J., and Tanaka, T. (2009) Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 446(1):18-27
Tanaka, T., Oka, T., Shimada, Y., Umemoto, N., Kuroyanagi, J., Sakamoto, C., Zang, L., Wang, Z., and Nishimura, Y. (2008) Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models. Journal of Pharmacological Sciences. 107(1):8-14

関連リンク

Tanaka Toshio in ZFIN

三重大学大学院医学系研究科システムズ薬理学HP

In Vivo
ハイスループット
スクリーニング

糖尿病治療薬

摂食抑制薬

血管新生阻害薬

薬物誘発性QT延長症候群

抗肥満薬

難聴治療薬

聴覚神経細胞障害