TOPICS

2018/06/07
Zebrafish-Based Drug Discovery and Systems Pharmacology

2017/12/01
フエノミクス個別化医療を実現

2017/11/25
Global Development in emerging zebrafish-based “alternative” methods

2017/11/25
ICH and 3Rs with zebrafish-based alternative methos

2017/11/23
171123日本動物実験代替法学会第 30 回大会シンポジウム6

》第135号 Flash News「がん治療の新たな光となる新規治療標的遺伝子を発見」 

                     
2014/09/30

第135号 Flash Newsに9/18の記者会見の模様が掲載されました。

Abstract

Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.
  

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Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression

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