TOPICS

2017/11/25
ICH and 3Rs with zebrafish-based alternative methos

2017/10/05
次世代個別化医療の実現に向けて

2017/09/29
ゼブラフィッシュによる次世代がん個別化医療と創薬支援システム開発

2017/09/12
Zebrafish-Based Drug Discovery and Pharmacophenomics

2017/06/25
具象(フェノタイプ)と抽象(ジェノタイプ)の二元論を、乗り越えて。

》第135号 Flash News「がん治療の新たな光となる新規治療標的遺伝子を発見」 

                     
2014/09/30

第135号 Flash Newsに9/18の記者会見の模様が掲載されました。

Abstract

Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.
  

関連リンク

Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression

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