TOPICS

2018/06/07
Zebrafish-Based Drug Discovery and Systems Pharmacology

2018/04/13
Zebrafish-Based Systems Pharmacology and Precision Medicine

2018/04/01
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2018/03/20
Patient-Derived Cancer Xenograft Zebrafish Model

2018/02/24
Zebrafish-Based Drug Discovery and Precision Pharmacology

tNext Generation Zebrafish-Driven Drug Discovery System and Personalized Medicine

                     
2014/12/10

We have developed zebrafish-based quantitative and systems pharmacology, which synergistically combine the desirable features of systems pharmacology and emerging technology of zebrafish-based screening system for functional omics and chemical biology. Zebrafish-based systems pharmacology that analyze in vivo regulatory networks involved in drug action can account for a drugfs multiple targets and for the effects of genomic, epigenomic, and posttranslational changes on the drug efficacy. The next generation discipline of systems pharmacology aims to combine experimental analysis and computational modeling of in vivo networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and catalyze the practice of personalized medicine. This new systems pharmacology can drive drug discovery and personalized medicine.

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